GDNF Receptor
Glial-cell-line-derived neurotrophic factor receptor
Glial-cell-line-derived neurotrophic factor receptor (GDNF receptor) is a class of cell surface receptors that can specifically recognize and bind to GDNF. By binding to GDNF, it can initiate the intracellular signal transduction process, thereby regulating various biological functions of cells such as growth, differentiation, and survival. GDNF receptor can guide the migration and differentiation of neurons, facilitate the survival of neurons and axonal guidance, and is crucial for the construction of the nervous system. In addition, GDNF receptor has a neuroprotective effect, which can protect neurons from various damaging factors such as oxidative stress and inflammation, and enable neurons to resist degeneration. GDNF receptor is closely related to the degeneration of neurons in neurodegenerative diseases, also plays an important role in the repair of spinal cord and peripheral nerve injuries, and its abnormal expression is also associated with the occurrence, development, and metastasis of tumors such as neuroblastoma[1][2].
References:
- [1]. Ibá?ez CF, et al. Biology of GDNF and its receptors - Relevance for disorders of the central nervous system. Neurobiol Dis. 2017 Jan;97(Pt B):80-89. [Content Brief]
- [2]. Baloh RH, et al. The GDNF family ligands and receptors - implications for neural development. Curr Opin Neurobiol. 2000 Feb;10(1):103-10. [Content Brief]
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GDNF Receptor Related Products (10)
Related Products (10)
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Antibodies (9)
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BT18
0 ImagesBT18 is a molecule mimic with function similar to glial cell line-derived neurotrophic factor (GDNF). BT18 shows an effect on GDNF family receptor GFRα1 and RET receptor tyrosine kinase RetA function.
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Hericene A
0 ImagesHericene A is an orally active aromatic hericene derivative. Hericene A exhibits anti-inflammatory and neurotrophic activities, and can found in the fruiting bodies of Hericium erinaceus. Hericene A inhibits the secretion of pro-inflammatory mediators. Hericene A promotes axonal growth, neurite branching, neurotrophic factor expression and downstream signal transduction. Hericene A can be used for the research of inflammatory and neurological diseases.
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GFRα2/3-IN-1
0 ImagesCat. No.: HY-163840GFRα2/3-IN-1 (Compound 16) is a selective GFRα2/3 inhibitor with IC50 values of 0.1 and 0.2 μM for GFRα2 and GFRα3, respectively. GFRα2 is a glial cell line-derived neurotrophic factor (GDNF) receptor related to GFRα1, GFRα2/3-IN-1 can be used for pain and itch research.
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Aminoquinol
0 ImagesCat. No.: HY-119910ACAS No.: 10023-54-8Synonyms: (E/Z)-XIB4035Aminoquinol is a GFRα-1 agonist. Aminoquinol exhibits neurotrophic effects similar to GDNF and induces Ret autophosphorylation in Neuro-2A cells. Aminoquinol can be used in research related to Parkinson's disease.
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Anti-Artemin Antibody
0 ImagesCat. No.: HY-P992192
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Anti-Neublastin Antibody
0 ImagesCat. No.: HY-P992271
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Anti-CNTFR Antibody
0 ImagesCat. No.: HY-P991945
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Aminoquinol phosphate
0 ImagesCat. No.: HY-119910BCAS No.: 7195-12-2Synonyms: (E/Z)-XIB4035 phosphateAminoquinol ((E/Z)-XIB4035) phosphate is a GFRα-1 agonist. Aminoquinol phosphate exhibits neurotrophic effects similar to GDNF and induces Ret autophosphorylation in Neuro-2A cells. Aminoquinol phosphate can be used in research related to Parkinson's disease.
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Aminoquinol triphosphate
0 ImagesCat. No.: HY-119910CCAS No.: 3653-53-0Synonyms: (E/Z)-XIB4035 triphosphateAminoquinol ((E/Z)-XIB4035) phosphate is a GFRα-1 agonist. Aminoquinol phosphate exhibits neurotrophic effects similar to GDNF and induces Ret autophosphorylation in Neuro-2A cells. Aminoquinol phosphate can be used in research related to Parkinson's disease.
